Journal article
Variations in the shape of the frontobasal brain region in obsessive-compulsive disorder
J Pujol, C Soriano-Mas, JD Gispert, M Bossa, S Reig, H Ortiz, P Alonso, N Cardoner, M López-Solà, BJ Harrison, J Deus, JM Menchón, M Desco, S Olmos
Human Brain Mapping | Published : 2011
DOI: 10.1002/hbm.21094
Abstract
Obsessive-compulsive disorder (OCD) emerges during childhood through young adulthood coinciding with the late phases of postnatal brain development when fine remodeling of brain anatomy takes place. Previous research has suggested the existence of subtle anatomical alterations in OCD involving focal volume variations in different brain regions including the frontal lobes and basal ganglia. We investigated whether anatomical changes might also involve variations in the shape of the frontobasal region. A total of 101 OCD patients and 101 control subjects were examined using magnetic resonance imaging. A cross-sectional image highly representative of frontal-basal ganglia anatomy was selected i..
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Grants
Awarded by Fondo de Investigaciones Sanitarias de la Seguridad Social, Spain
Awarded by Ministry of Education and Science of Spain
Awarded by National Health and Medical Research Council of Australia (NHMRC)
Funding Acknowledgements
Contract grant sponsor: Fondo de Investigaciones Sanitarias de la Seguridad Social, Spain; Contract grant numbers: PI071029, PI071044, CIBER-CB06/03/0034, AP2005-0408 (to M.L.-S); Contract grant sponsor: Ministry of Education and Science of Spain (to H.O.); Contract grant number: AP2006-2869; Contract grant sponsor: National Health and Medical Research Council of Australia (NHMRC) Clinical Career Development Award; Contract grant number: 628509 (to B.J.H.).